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Due to the increasing public interest in Tamiflu, Roche continues to inform physicians and government representatives about the situation, and presents new data on the issue of sustainability. In patients infected with H5N1 ( «avian flu"), been no new cases of resistance to the drug since March 2005, and the results of scientific research has not found evidence of increased resistance to Tamiflu (oseltamivir). Roche is providing new information on the subject, so that all interested persons to continue to use Tamiflu as an effective drug for the treatment and prevention of seasonal influenza and the virus H5N1. "In the past few months there has been erroneous information that the patients increased resistance to Tamiflu. Roche and independent groups have been closely monitoring all the data in this area, and the scientific evidence for this is not found, - said William M. Burns, CEO Division Roche Pharma. "Governments can be confident that Tamiflu as a key agent in accordance with WHO recommendations, the formation of reserves to deal with pandemic influenza, which will be used by doctors and patients for treatment and prevention during seasonal outbreaks of infection." Stability is not increased As with any antiviral medication, there is a theoretical risk that a virus may emerge with decreased sensitivity to it. Roche records all instances of resistance to Tamiflu in the company and external organizations, working with such of them as the Neuraminidase Inhibitor Susceptibility Network (NISN). Data obtained from observations of thousands of patients worldwide who have been treated with Tamiflu for seasonal influenza, in general, show that the incidence of resistant virus is very low - 0.32% in adults and 4.1% in children. The higher incidence of resistant virus among children compared with adults is caused mainly by higher levels of virus and longer duration of viral shedding. In one small study in children in Japan, was found a higher degree of stability. But in this study, children often receive a much lower dosage of medication than children who took the drug in the West, and some of the children in Japan were receiving medication within much shorter period than the recommended 5 days. Analysis of the drug during an epidemic in Japan, where Tamiflu received approximately 32 million patients, showed that low rates of resistance remained, and in this case. Most of viruses, of which there is evidence that they are resistant to Tamiflu, are cause less severe infections and have a much lower ability to spread. Stability of avian influenza virus H5N1 In terms of planning and preparedness for a pandemic of particular concern is the possible development of resistance to Tamiflu by the virus. However, to date there have only been three cases of Tamiflu resistance in avian flu virus H5N1. In the first case of a patient who is already exhibiting clinical symptoms, was introduced prophylactic dose (75 mg daily) rather than a therapeutic dose (75 mg twice daily), and this low intake increases the risk of resistance. After the dose was increased to two times a day, the patient recovered. It should be noted that the H5N1 virus is different in that the agent is less severe infection, which also have less capacity to spread. In two other cases, the recommended dose and duration of oseltamivir. One of the two patients received treatment on the second day after the onset of the disease, treatment of the second patient started on the sixth day of illness. Since March 2005, was not identified or reported no cases of H5N1 resistance to Tamiflu, despite the fact that the number of infected patients is increasing. In a recent study has also shown that the virus H5N1, isolated in 2004 and 2005. More sensitive (about 10 times) to oseltamivir, the virus than H5N1, isolated in 1997, as well as acting in the present seasonal virus ( H1N1). Thus, it is clear that over time the sensitivity of the virus to Tamiflu. About Tamiflu 75 mg Tamiflu is designed as an effective tool for prevention and treatment of influenza types A and B. Its action consists in blocking the action of the neuraminidase protein on the surface of the virus. When neuraminidase is inhibited, the virus loses its ability to spread and infect other cells. Tamiflu is licensed for the treatment and prevention of influenza in adults and children aged one year. Roche's efforts to support governments of the world in the formation of reserves to fight epidemics World Health Organization (WHO) said that to date the only effective way to prepare to fight a possible pandemic influenza is the early formation of stockpiles of antiviral drugs. Roche is working closely with WHO and the governments of various countries in the establishment of such reserves. The Company has received and fulfilled orders to create stockpiles of drugs in more than 75 countries worldwide. The volume of these orders varies from country to country: for example, in countries such as France, Finland, Iceland, Ireland, Luxembourg, Netherlands, New Zealand, Norway, Switzerland and UK stockpiling or intending to stockpile adequate Tamiflu to cover 20-40% of the population these countries. Roche has also made a donation of 5.125 million treatment courses of Tamiflu to the WHO for urgent international support and the maturity of possible regional outbreak of the flu and prevent a pandemic. Roche and Gilead Tamiflu was invented by Gilead Sciences and licensed to Roche in 1996. Roche and Gilead partnered on clinical development, with Roche in the framework of cooperation is responsible for the production, registration and distribution of products in the world market. In accordance with the terms of the contract between the companies from November 2005, Gilead with Roche is involved in obtaining sub-licenses for the supply of oseltamivir in the fund to prevent a pandemic. To ensure broader access to Tamiflu for all patients in need, the company Gilead agreed to waive its right to receive full payments for product sold under these sub-licenses. About Roche Roche is one of the market leaders in health care, are among the ten largest companies in the world in the field of pharmaceuticals, but also ranks first in the world in the field of diagnostics. The main purpose of Roche - production and promotion of innovative products and advanced diagnostic tools, which allow to save patients' lives significantly extend and improve the quality of their lives. 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Published list of drugs that are effective with swine influenza

FDA published official recommendations for the treatment of swine influenza. According to these instructions, to combat the disease can be applied two antiviral drugs: oseltamivir (Tamflyu, Roche) and similar zanamivir (Relenza, Glaxo).

Other popular suppressing anti drugs - and that amantadine and remantadin - recognized neeffektvinymi.

The vaccine is from this strain in the near future is expected. Its creation will take at least 6 months. Currently, WHO will ensure that, before the vaccine Mexico will be provided these antiviral drugs. It is already actively working with pharmaceutical holdings.

The representative of Roche Holding AG, manufacturer of the drug Tamiflu, said that before the WHO has a reserve for the treatment of five million people.
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